Q01082

FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SUBUNIT: Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers. The short form cannot bind to the axonal protein fodaxin. Interacts with ANK2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes (By similarity). SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=Q01082-1; Sequence=Displayed; Name=Short; IsoId=Q01082-2; Sequence=VSP_000720, VSP_000721; Name=2; IsoId=Q01082-3; Sequence=VSP_026054, VSP_026055, VSP_026056; Note=Phosphorylated on Ser-8 (By similarity), Ser-10 and Ser-14; TISSUE SPECIFICITY: Isoform 2 is present in brain, lung and kidney (at protein level). PTM: Isoform 2 is phosphorylated on Ser-8 and Ser-10 (By similarity). SIMILARITY: Belongs to the spectrin family. SIMILARITY: Contains 2 CH (calponin-homology) domains. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 17 spectrin repeats. SEQUENCE CAUTION: Sequence=BAD92985.1; Type=Erroneous initiation; GENE SYNONYMS:SPTBN1 SPTB2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 2364 AA; 274609 MW; 1770C3B0EB07B892 CRC64;

SPTB2_HUMAN

urn:biopax:ModificationFeature:SPTB2_HUMAN_1, urn:biopax:ModificationFeature:SPTB2_HUMAN_10, urn:biopax:ModificationFeature:SPTB2_HUMAN_11, urn:biopax:ModificationFeature:SPTB2_HUMAN_12, urn:biopax:ModificationFeature:SPTB2_HUMAN_13, urn:biopax:ModificationFeature:SPTB2_HUMAN_14, urn:biopax:ModificationFeature:SPTB2_HUMAN_15, urn:biopax:ModificationFeature:SPTB2_HUMAN_16, urn:biopax:ModificationFeature:SPTB2_HUMAN_17, urn:biopax:ModificationFeature:SPTB2_HUMAN_18, urn:biopax:ModificationFeature:SPTB2_HUMAN_19, urn:biopax:ModificationFeature:SPTB2_HUMAN_2, urn:biopax:ModificationFeature:SPTB2_HUMAN_20, urn:biopax:ModificationFeature:SPTB2_HUMAN_21, urn:biopax:ModificationFeature:SPTB2_HUMAN_22, urn:biopax:ModificationFeature:SPTB2_HUMAN_23, urn:biopax:ModificationFeature:SPTB2_HUMAN_3, urn:biopax:ModificationFeature:SPTB2_HUMAN_4, urn:biopax:ModificationFeature:SPTB2_HUMAN_5, urn:biopax:ModificationFeature:SPTB2_HUMAN_6, urn:biopax:ModificationFeature:SPTB2_HUMAN_7, urn:biopax:ModificationFeature:SPTB2_HUMAN_8, urn:biopax:ModificationFeature:SPTB2_HUMAN_9

MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK