Linked Life Data

P81605

Source:http://identifiers.org/uniprot/P81605

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. FUNCTION: Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. COFACTOR: Manganese. Required for survival-promoting peptide. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P81605-1; Sequence=Displayed; Name=2; IsoId=P81605-2; Sequence=VSP_043767; Name=3; IsoId=P81605-3; Sequence=VSP_043765, VSP_043766; TISSUE SPECIFICITY: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml. MASS SPECTROMETRY: Mass=4702.57; Method=Electrospray; Range=63- 109; Source=PubMed:11694882; WEB RESOURCE: Name=Protein Spotlight; Note=Smart sweat - Issue 18 of January 2002; URL="http://web.expasy.org/spotlight/back_issues/sptlt018.shtml"; GENE SYNONYMS:DCD AIDD DSEP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 110 AA; 11284 MW; 23666FBD20019465 CRC64;
biopax3:xref
biopax3:displayName
DCD_HUMAN
biopax3:name
3.4.-.-, DCD, DCD-1, Preproteolysin, Survival-promoting peptide
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
biopax3:standardName
Dermcidin