| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. COFACTOR: Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed with highest levels in heart and lowest levels in lung and liver. DEVELOPMENTAL STAGE: Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase. SIMILARITY: Belongs to the Nth/MutY family. CAUTION: It is uncertain whether Met-1, Met-9 or Met-16 is the initiator. SEQUENCE CAUTION: Sequence=AAC51136.1; Type=Erroneous initiation; Sequence=AAH03014.1; Type=Erroneous initiation; Sequence=BAA19413.1; Type=Erroneous initiation; Sequence=BAA32695.1; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nthl1/"; GENE SYNONYMS:NTHL1 NTH1 OCTS3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 312 AA; 34390 MW; 379816A1E0B45050 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8028,
urn:biopax:RelationshipXref:NCBI GENE_4913,
urn:biopax:RelationshipXref:REFSEQ_NP_002519,
urn:biopax:UnificationXref:UNIPROT_P78549,
urn:biopax:UnificationXref:UNIPROT_Q1MVR1,
urn:biopax:UnificationXref:UNIPROT_Q99566,
urn:biopax:UnificationXref:UNIPROT_Q99794,
urn:biopax:UnificationXref:UNIPROT_Q9BPX2
|
| biopax3:displayName |
NTHL1_HUMAN
|
| biopax3:name |
4.2.99.18,
NTHL1
|
| biopax3:organism | |
| biopax3:sequence |
MCSPQESGMTALSARMLTRSRSLGPGAGPRGCREEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLVNIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLPVHPRCHACLNQALCPAAQGL
|
| biopax3:standardName |
Endonuclease III-like protein 1
|