| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. CATALYTIC ACTIVITY: L-arginine + H(2)O = L-ornithine + urea. COFACTOR: Binds 2 manganese ions per subunit. PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. SIMILARITY: Belongs to the arginase family. WEB RESOURCE: Name=Wikipedia; Note=Arginase entry; URL="http://en.wikipedia.org/wiki/Arginase"; GENE SYNONYMS:ARG2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 354 AA; 38578 MW; 1624FAC7D515C68B CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
ARGI2_HUMAN
|
| biopax3:name |
3.5.3.1,
ARG2,
Kidney-type arginase,
Non-hepatic arginase,
Type II arginase
|
| biopax3:organism | |
| biopax3:sequence |
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
|
| biopax3:standardName |
Arginase-2, mitochondrial
|