| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate; Vmax=0.2 pmol/min/ug enzyme; SUBUNIT: Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78356-1; Sequence=Displayed; Name=2; IsoId=P78356-2; Sequence=VSP_010384, VSP_010385; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. PTM: Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. SIMILARITY: Contains 1 PIPK domain. GENE SYNONYMS:PIP4K2B PIP5K2B. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 416 AA; 47378 MW; 2288CD2883EACEBE CRC64;
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| biopax3:xref | |
| biopax3:displayName |
PI42B_HUMAN
|
| biopax3:name |
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta,
2.7.1.149,
Diphosphoinositide kinase 2-beta,
PI(5)P 4-kinase type II beta,
PIP4K2B,
PIP4KII-beta,
Phosphatidylinositol 5-phosphate 4-kinase type II beta,
PtdIns(5)P-4-kinase isoform 2-beta
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
|
| biopax3:standardName |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
|