Linked Life Data

P62994

Source:http://identifiers.org/uniprot/P62994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity). SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains. Interacts with CBL and CBLB. Interacts with AJUBA (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1, SKAP2 and CLNK (By similarity). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains SH2 domain with phosphorylated MUC1. Interacts with PRNP (By similarity). Interacts with NISCH, RALGPS1 and with HCST (By similarity). Interacts with GAPT, THEMIS and PTPRE (By similarity). Interacts (via SH3 2) with GAB2 (By similarity). Interacts with ADAM15. Interacts with PTPRJ and BCR (By similarity). Interacts with THEMIS2. Interacts (via SH2 domain) with AXL and KIT (phosphorylated). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (By similarity). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PTPN23 (By similarity). Interacts with FLT1, KDR and FLT4 (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL, in which GRB2 promotes RTK recruitment by TNK2 (By similarity). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Interacts with PTPN11. Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts with ERBB4. Interacts with PTK2/FAK1 (tyrosine phosphorylated). Interacts with SCIMP (By similarity). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Endosome (By similarity). Golgi apparatus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist; Name=1; Synonyms=Ash-L; IsoId=P62994-1, P29354-1; Sequence=Displayed; Name=2; Synonyms=Ash-M; IsoId=P62994-2, P29354-3; Sequence=VSP_001840; Name=3; Synonyms=Ash-S; IsoId=P62994-3, P29354-4; Sequence=VSP_001838; TISSUE SPECIFICITY: Wide tissue distribution. DOMAIN: The SH3 domains mediate interaction with RALGPS1 and SHB (By similarity). SIMILARITY: Belongs to the GRB2/sem-5/DRK family. SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 2 SH3 domains. GENE SYNONYMS:Grb2 Ash. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
biopax3:xref
biopax3:displayName
GRB2_RAT
biopax3:name
Adapter protein GRB2, Grb2, Protein Ash, SH2/SH3 adapter GRB2
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
biopax3:standardName
Growth factor receptor-bound protein 2