| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. SUBUNIT: Found in the multi-protein complexes: the 26S proteasome (formed from the 20S proteasome and PA700), and the modulator. PA700 consists of 28 subunits arranged to form a cylinder-shaped complex by four stacked rings, each containing seven subunits. Interacts with PAAF1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the AAA ATPase family. CAUTION: Alternative initiation from an upstream conserved methionine cannot be fully excluded but is not experimentally supported while initiation from the displayed methionine is supported by PubMed:17323924. GENE SYNONYMS:PSMC6 SUG2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 389 AA; 44173 MW; B26421295742CACD CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:9553,
urn:biopax:RelationshipXref:NCBI GENE_5706,
urn:biopax:RelationshipXref:REFSEQ_NP_002797,
urn:biopax:UnificationXref:UNIPROT_B2R975,
urn:biopax:UnificationXref:UNIPROT_P49719,
urn:biopax:UnificationXref:UNIPROT_P62333,
urn:biopax:UnificationXref:UNIPROT_Q6IBU3,
urn:biopax:UnificationXref:UNIPROT_Q92524
|
| biopax3:displayName |
PRS10_HUMAN
|
| biopax3:name |
26S proteasome AAA-ATPase subunit RPT4,
PSMC6,
Proteasome 26S subunit ATPase 6,
Proteasome subunit p42
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
|
| biopax3:standardName |
26S protease regulatory subunit 10B
|