| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. SUBCELLULAR LOCATION: Secreted. DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. PHARMACEUTICAL: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma. SIMILARITY: Belongs to the IL-2 family. SEQUENCE CAUTION: Sequence=AAA59140.1; Type=Erroneous initiation; WEB RESOURCE: Name=R&D Systems' cytokine source book: IL-2; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1638"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-2 entry; URL="http://en.wikipedia.org/wiki/Interleukin_2"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il2/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL2"; GENE SYNONYMS:IL2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 153 AA; 17628 MW; 59E2F40F25860F84 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
IL2_HUMAN
|
| biopax3:name |
Aldesleukin,
IL-2,
IL2,
T-cell growth factor,
TCGF
|
| biopax3:organism | |
| biopax3:sequence |
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
|
| biopax3:standardName |
Interleukin-2
|