| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). ENZYME REGULATION: By intracellular calcium ions (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=3; Synonyms=NCX3.3; IsoId=P57103-1; Sequence=Displayed; Name=2; Synonyms=NCX3.2; IsoId=P57103-2; Sequence=VSP_008116; Name=4; Synonyms=NCX3.4; IsoId=P57103-3; Sequence=VSP_008117, VSP_008118; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available; Name=5; Synonyms=NCX3-tN.1; IsoId=P57103-4; Sequence=VSP_043125; Note=Expressed in fetal brain; Name=6; Synonyms=NCX3-tN.2; IsoId=P57103-5; Sequence=VSP_043126, VSP_008116; Note=Expressed in fetal brain; Name=7; IsoId=P57103-6; Sequence=VSP_043850; TISSUE SPECIFICITY: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. SIMILARITY: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. SIMILARITY: Contains 2 Calx-beta domains. GENE SYNONYMS:SLC8A3 NCX3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 927 AA; 103010 MW; 7B43CB6A9D77615E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11070,
urn:biopax:RelationshipXref:NCBI GENE_6547,
urn:biopax:RelationshipXref:REFSEQ_NP_001123889,
urn:biopax:RelationshipXref:REFSEQ_NP_150287,
urn:biopax:RelationshipXref:REFSEQ_NP_489479,
urn:biopax:RelationshipXref:REFSEQ_NP_891977,
urn:biopax:RelationshipXref:REFSEQ_NP_891981,
urn:biopax:RelationshipXref:REFSEQ_NP_892114,
urn:biopax:UnificationXref:UNIPROT_P57103,
urn:biopax:UnificationXref:UNIPROT_Q5K3P6,
urn:biopax:UnificationXref:UNIPROT_Q5K3P7,
urn:biopax:UnificationXref:UNIPROT_Q8IUE9,
urn:biopax:UnificationXref:UNIPROT_Q8IUF0,
urn:biopax:UnificationXref:UNIPROT_Q8NFI7,
urn:biopax:UnificationXref:UNIPROT_Q96QG1
|
| biopax3:displayName |
NAC3_HUMAN
|
| biopax3:name |
Na(+)/Ca(2+)-exchange protein 3,
SLC8A3
|
| biopax3:organism | |
| biopax3:sequence |
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
|
| biopax3:standardName |
Sodium/calcium exchanger 3
|