| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Responsible for the reduction of the keto group on the C-3 of sterols. CATALYTIC ACTIVITY: 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP(+) = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH. CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H. PATHWAY: Steroid biosynthesis; estrogen biosynthesis. PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56937-1; Sequence=Displayed; Name=2; IsoId=P56937-2; Sequence=VSP_006029; Name=3; IsoId=P56937-3; Sequence=VSP_012766; TISSUE SPECIFICITY: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells. PTM: Phosphorylated. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. GENE SYNONYMS:HSD17B7. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 341 AA; 38206 MW; FE4892B2602F549B CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5215,
urn:biopax:RelationshipXref:NCBI GENE_51478,
urn:biopax:RelationshipXref:REFSEQ_NP_057455,
urn:biopax:UnificationXref:UNIPROT_P56937,
urn:biopax:UnificationXref:UNIPROT_Q5T246,
urn:biopax:UnificationXref:UNIPROT_Q7Z4V9,
urn:biopax:UnificationXref:UNIPROT_Q8WWS2,
urn:biopax:UnificationXref:UNIPROT_Q9UF00
|
| biopax3:displayName |
DHB7_HUMAN
|
| biopax3:name |
1.1.1.270,
1.1.1.62,
17-beta-HSD 7,
17-beta-hydroxysteroid dehydrogenase 7,
Estradiol 17-beta-dehydrogenase 7,
HSD17B7
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
|
| biopax3:standardName |
3-keto-steroid reductase
|