| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme. SUBUNIT: Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS. Interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56645-1; Sequence=Displayed; Name=2; IsoId=P56645-2; Sequence=VSP_040326, VSP_040327, VSP_040328; PTM: Phosphorylation appears to require association with PER1 and translocation to the nucleus (By similarity). PTM: Ubiquitinated (By similarity). SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains. SEQUENCE CAUTION: Sequence=BAB32925.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:PER3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1201 AA; 131888 MW; 8129C4246EDD1816 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8847,
urn:biopax:RelationshipXref:NCBI GENE_8863,
urn:biopax:RelationshipXref:REFSEQ_NP_058515,
urn:biopax:UnificationXref:UNIPROT_P56645,
urn:biopax:UnificationXref:UNIPROT_Q5H8X4,
urn:biopax:UnificationXref:UNIPROT_Q5H8X5,
urn:biopax:UnificationXref:UNIPROT_Q969K6,
urn:biopax:UnificationXref:UNIPROT_Q96S77,
urn:biopax:UnificationXref:UNIPROT_Q96S78,
urn:biopax:UnificationXref:UNIPROT_Q9C0J3,
urn:biopax:UnificationXref:UNIPROT_Q9NSP9,
urn:biopax:UnificationXref:UNIPROT_Q9UGU8
|
| biopax3:displayName |
PER3_HUMAN
|
| biopax3:name |
Cell growth-inhibiting gene 13 protein,
Circadian clock protein PERIOD 3,
PER3,
hPER3
|
| biopax3:organism | |
| biopax3:sequence |
MPRGEAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFPSERRNKPSTLDALNYALRCVHSVQANSEFFQILSQNGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAHTARAQLPFWNNWTQRAARYECAPVKPFFCRIRGGEDRKQEKCHSPFRIIPYLIHVHHPAQPELESEPCCLTVVEKIHSGYEAPRIPVNKRIFTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWSSFVNPWSRKISFIIGRHKVRTSPLNEDVFATKIKKMNDNDKDITELQEQIYKLLLQPVHVSVSSGYGSLGSSGSQEQLVSIASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQLYIESMTKSSFKPVTGTRTEPNGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPSYQQINCIDSVIRYLKSYNIPALKRKCISCTNTTSSSSEEDKQNHKADDVQALQAGLQIPAIPKSEMPTNGRSIDTGGGAPQILSTAMLSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGLTAAVLSAHTQKEEQNYVDKFREKILSSPYSSYLQQESRSKAKYSYFQGDSTSKQTRSAGCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQRREEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLTSSVYSSKISQNGQQSQDVQKKETFPNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQKEELAKVYNWIQSQTVTQEIDIQACVTCENEDSADGAATSCGQVLVEDSC
|
| biopax3:standardName |
Period circadian protein homolog 3
|