| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. INDUCTION: Specifically induced in macrophages by IL4/interleukin- 4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB. MASS SPECTROMETRY: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396; MASS SPECTROMETRY: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396; MASS SPECTROMETRY: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396; SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. WEB RESOURCE: Name=Wikipedia; Note=CCL18 entry; URL="http://en.wikipedia.org/wiki/CCL18"; GENE SYNONYMS:CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 89 AA; 9849 MW; C287B94B9C0518E4 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
CCL18_HUMAN
|
| biopax3:name |
AMAC-1,
Alternative macrophage activation-associated CC chemokine 1,
CC chemokine PARC,
CCL18,
CCL18(1-68),
CCL18(3-69),
CCL18(4-69),
DC-CK1,
Dendritic cell chemokine 1,
MIP-4,
Macrophage inflammatory protein 4,
Pulmonary and activation-regulated chemokine,
Small-inducible cytokine A18
|
| biopax3:organism | |
| biopax3:sequence |
MKGLAAALLVLVCTMALCSCAQVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA
|
| biopax3:standardName |
C-C motif chemokine 18
|