| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. CATALYTIC ACTIVITY: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val- Asp-|-. ENZYME REGULATION: Inhibited by isatin sulfonamides. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=P55210-1; Sequence=Displayed; Name=Beta; IsoId=P55210-2; Sequence=VSP_000807; Note=Lacks enzymatic activity; Name=Alpha'; Synonyms=Beta; IsoId=P55210-3; Sequence=VSP_000806; Note=What we call isoform Alpha' is also known as Beta (PubMed:9070923); TISSUE SPECIFICITY: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. PTM: Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. SIMILARITY: Belongs to the peptidase C14A family. GENE SYNONYMS:CASP7 MCH3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 303 AA; 34277 MW; CD373EE54A232CA4 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1508,
urn:biopax:RelationshipXref:NCBI GENE_840,
urn:biopax:RelationshipXref:REFSEQ_NP_001218,
urn:biopax:RelationshipXref:REFSEQ_NP_203124,
urn:biopax:RelationshipXref:REFSEQ_NP_203125,
urn:biopax:RelationshipXref:REFSEQ_NP_203126,
urn:biopax:UnificationXref:UNIPROT_B5BU45,
urn:biopax:UnificationXref:UNIPROT_D3DRB8,
urn:biopax:UnificationXref:UNIPROT_P55210,
urn:biopax:UnificationXref:UNIPROT_Q13364,
urn:biopax:UnificationXref:UNIPROT_Q53YD5,
urn:biopax:UnificationXref:UNIPROT_Q5SVL0,
urn:biopax:UnificationXref:UNIPROT_Q5SVL3,
urn:biopax:UnificationXref:UNIPROT_Q96BA0
|
| biopax3:displayName |
CASP7_HUMAN
|
| biopax3:name |
3.4.22.60,
Apoptotic protease Mch-3,
CASP-7,
CASP7,
CMH-1,
Caspase-7 subunit p11,
Caspase-7 subunit p20,
ICE-LAP3,
ICE-like apoptotic protease 3
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
|
| biopax3:standardName |
Caspase-7
|