| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). SUBUNIT: Homodimer. Interacts with CSTF2. SUBCELLULAR LOCATION: Nucleus. PTM: Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N- terminal Ser-rich region. MASS SPECTROMETRY: Mass=14266; Mass_error=4; Method=MALDI; Range=2-127; Source=PubMed:7809103; MASS SPECTROMETRY: Mass=14263; Method=Electrospray; Range=2-127; Source=PubMed:16689930; SIMILARITY: Belongs to the transcriptional coactivator PC4 family. GENE SYNONYMS:SUB1 PC4 RPO2TC1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 127 AA; 14395 MW; 0DAE0CAAAD5E4E15 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
TCP4_HUMAN
|
| biopax3:name |
PC4,
Positive cofactor 4,
SUB1,
SUB1 homolog,
p14
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:TCP4_HUMAN_1,
urn:biopax:ModificationFeature:TCP4_HUMAN_10,
urn:biopax:ModificationFeature:TCP4_HUMAN_11,
urn:biopax:ModificationFeature:TCP4_HUMAN_12,
urn:biopax:ModificationFeature:TCP4_HUMAN_13,
urn:biopax:ModificationFeature:TCP4_HUMAN_14,
urn:biopax:ModificationFeature:TCP4_HUMAN_15,
urn:biopax:ModificationFeature:TCP4_HUMAN_16,
urn:biopax:ModificationFeature:TCP4_HUMAN_2,
urn:biopax:ModificationFeature:TCP4_HUMAN_3,
urn:biopax:ModificationFeature:TCP4_HUMAN_4,
urn:biopax:ModificationFeature:TCP4_HUMAN_5,
urn:biopax:ModificationFeature:TCP4_HUMAN_6,
urn:biopax:ModificationFeature:TCP4_HUMAN_7,
urn:biopax:ModificationFeature:TCP4_HUMAN_8,
urn:biopax:ModificationFeature:TCP4_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MPKSKELVSSSSSGSDSDSEVDKKLKRKKQVAPEKPVKKQKTGETSRALSSSKQSSSSRDDNMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKGISLNPEQWSQLKEQISDIDDAVRKL
|
| biopax3:standardName |
Activated RNA polymerase II transcriptional coactivator p15
|