| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). SUBUNIT: Interacts (via SH2 domains) with the phosphorylated form of EPHA2 (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P52735-1; Sequence=Displayed; Name=2; IsoId=P52735-2; Sequence=VSP_034900, VSP_034901; Name=3; IsoId=P52735-3; Sequence=VSP_034900, VSP_034901, VSP_034902; TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated on tyrosine residues in response to FGR activation. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 2 SH3 domains. GENE SYNONYMS:VAV2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 878 AA; 101289 MW; C186911605FD5B73 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:12658,
urn:biopax:RelationshipXref:NCBI GENE_7410,
urn:biopax:RelationshipXref:REFSEQ_NP_001127870,
urn:biopax:RelationshipXref:REFSEQ_NP_003362,
urn:biopax:UnificationXref:UNIPROT_A2RUM4,
urn:biopax:UnificationXref:UNIPROT_A8MQ12,
urn:biopax:UnificationXref:UNIPROT_B6ZDF5,
urn:biopax:UnificationXref:UNIPROT_P52735,
urn:biopax:UnificationXref:UNIPROT_Q5SYV3,
urn:biopax:UnificationXref:UNIPROT_Q5SYV4,
urn:biopax:UnificationXref:UNIPROT_Q5SYV5,
urn:biopax:UnificationXref:UNIPROT_Q6N012,
urn:biopax:UnificationXref:UNIPROT_Q6PIJ9,
urn:biopax:UnificationXref:UNIPROT_Q6Q317
|
| biopax3:displayName |
VAV2_HUMAN
|
| biopax3:name |
VAV-2,
VAV2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
|
| biopax3:standardName |
Guanine nucleotide exchange factor VAV2
|