Linked Life Data

P51959

Source:http://identifiers.org/uniprot/P51959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). SUBCELLULAR LOCATION: Nucleus. Note=DNA replication foci after DNA damage. TISSUE SPECIFICITY: High levels in skeletal muscle, ovary, kidney and colon. DEVELOPMENTAL STAGE: Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle. INDUCTION: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage. SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily. SEQUENCE CAUTION: Sequence=AAB03903.1; Type=Erroneous initiation; Sequence=CAA54821.1; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccng1/"; GENE SYNONYMS:CCNG1 CCNG CYCG1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 295 AA; 34074 MW; EA0B02C83F3B6BF3 CRC64;
biopax3:xref
biopax3:displayName
CCNG1_HUMAN
biopax3:name
CCNG1, Cyclin-G
biopax3:organism
biopax3:sequence
MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP
biopax3:standardName
Cyclin-G1