| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. SUBUNIT: Interacts with GIPC PDZ domain. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. PTM: Fatty acylated. Heavily palmitoylated in the cysteine string motif. PTM: Phosphorylated, mainly on serine residues. SIMILARITY: Contains 1 RGS domain. GENE SYNONYMS:RGS19 GAIP GNAI3IP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 217 AA; 24636 MW; 925A5687DC222CBD CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:13735,
urn:biopax:RelationshipXref:NCBI GENE_10287,
urn:biopax:RelationshipXref:REFSEQ_NP_001034556,
urn:biopax:RelationshipXref:REFSEQ_NP_005864,
urn:biopax:UnificationXref:UNIPROT_A8K216,
urn:biopax:UnificationXref:UNIPROT_E1P5G9,
urn:biopax:UnificationXref:UNIPROT_P49795,
urn:biopax:UnificationXref:UNIPROT_Q53XN0,
urn:biopax:UnificationXref:UNIPROT_Q8TD60
|
| biopax3:displayName |
RGS19_HUMAN
|
| biopax3:name |
G-alpha-interacting protein,
GAIP,
RGS19
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
|
| biopax3:standardName |
Regulator of G-protein signaling 19
|