| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. SUBUNIT: Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p72; IsoId=P49757-1; Sequence=Displayed; Name=2; Synonyms=p66; IsoId=P49757-2; Sequence=VSP_004349; Name=3; Synonyms=p71; IsoId=P49757-3; Sequence=VSP_004348; Name=4; Synonyms=p65; IsoId=P49757-4; Sequence=VSP_004348, VSP_004349; PTM: Phosphorylated on Ser-276 and Ser-295 by CaMK1 (By similarity). PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. SIMILARITY: Contains 1 PID domain. SEQUENCE CAUTION: Sequence=AAH20788.1; Type=Miscellaneous discrepancy; Note=Intron retention; GENE SYNONYMS:NUMB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 651 AA; 70804 MW; 5B590BE49A74FCF2 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8060,
urn:biopax:RelationshipXref:NCBI GENE_8650,
urn:biopax:RelationshipXref:REFSEQ_NP_001005743,
urn:biopax:RelationshipXref:REFSEQ_NP_001005744,
urn:biopax:RelationshipXref:REFSEQ_NP_001005745,
urn:biopax:RelationshipXref:REFSEQ_NP_003735,
urn:biopax:UnificationXref:UNIPROT_B4E2B1,
urn:biopax:UnificationXref:UNIPROT_P49757,
urn:biopax:UnificationXref:UNIPROT_Q6NUQ7,
urn:biopax:UnificationXref:UNIPROT_Q86SY1,
urn:biopax:UnificationXref:UNIPROT_Q8WW73,
urn:biopax:UnificationXref:UNIPROT_Q9UBG1,
urn:biopax:UnificationXref:UNIPROT_Q9UEQ4,
urn:biopax:UnificationXref:UNIPROT_Q9UKE8,
urn:biopax:UnificationXref:UNIPROT_Q9UKE9,
urn:biopax:UnificationXref:UNIPROT_Q9UKF0,
urn:biopax:UnificationXref:UNIPROT_Q9UQJ4
|
| biopax3:displayName |
NUMB_HUMAN
|
| biopax3:name |
NUMB,
Protein S171,
h-Numb
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:NUMB_HUMAN_1,
urn:biopax:ModificationFeature:NUMB_HUMAN_2,
urn:biopax:ModificationFeature:NUMB_HUMAN_3,
urn:biopax:ModificationFeature:NUMB_HUMAN_4,
urn:biopax:ModificationFeature:NUMB_HUMAN_5,
urn:biopax:ModificationFeature:NUMB_HUMAN_6,
urn:biopax:ModificationFeature:NUMB_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
|
| biopax3:standardName |
Protein numb homolog
|