| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). FUNCTION: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. FUNCTION: Isoform 3 mediates the activity of CXCL11. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CXCR3-A; IsoId=P49682-1; Sequence=Displayed; Name=2; Synonyms=CXCR3-B; IsoId=P49682-2; Sequence=VSP_015684; Name=3; Synonyms=CXCR3-alt; IsoId=P49682-3; Sequence=VSP_015685; Note=Due to exon skipping; TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. PTM: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. PTM: N-glycosylated. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SEQUENCE CAUTION: Sequence=CAB02143.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CXCR3ID40224chXq13.html"; WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CXC_chemokine_receptors"; GENE SYNONYMS:CXCR3 GPR9. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 368 AA; 40660 MW; F08A3B44B2BBAD04 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4540,
urn:biopax:RelationshipXref:NCBI GENE_2833,
urn:biopax:RelationshipXref:REFSEQ_NP_001136269,
urn:biopax:RelationshipXref:REFSEQ_NP_001495,
urn:biopax:UnificationXref:UNIPROT_B2R982,
urn:biopax:UnificationXref:UNIPROT_O15185,
urn:biopax:UnificationXref:UNIPROT_P49682,
urn:biopax:UnificationXref:UNIPROT_Q7Z710,
urn:biopax:UnificationXref:UNIPROT_Q9P2T4,
urn:biopax:UnificationXref:UNIPROT_Q9P2T5
|
| biopax3:displayName |
CXCR3_HUMAN
|
| biopax3:name |
CD183,
CKR-L2,
CXC-R3,
CXCR-3,
CXCR3,
G protein-coupled receptor 9,
IP-10 receptor,
Interferon-inducible protein 10 receptor
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
|
| biopax3:standardName |
C-X-C chemokine receptor type 3
|