| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48729-1; Sequence=Displayed; Name=2; IsoId=P48729-2; Sequence=VSP_035455; Note=Phosphorylated on Ser-156; SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/CSNK1A1ID40168ch5q32.html"; GENE SYNONYMS:CSNK1A1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 337 AA; 38915 MW; 1B2085AE33CAFAC2 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2451,
urn:biopax:RelationshipXref:NCBI GENE_1452,
urn:biopax:RelationshipXref:REFSEQ_NP_001020276,
urn:biopax:RelationshipXref:REFSEQ_NP_001883,
urn:biopax:UnificationXref:UNIPROT_D3DQG0,
urn:biopax:UnificationXref:UNIPROT_D3DQG1,
urn:biopax:UnificationXref:UNIPROT_P48729,
urn:biopax:UnificationXref:UNIPROT_Q4JJA0,
urn:biopax:UnificationXref:UNIPROT_Q5U046,
urn:biopax:UnificationXref:UNIPROT_Q5U047,
urn:biopax:UnificationXref:UNIPROT_Q6FGA2,
urn:biopax:UnificationXref:UNIPROT_Q96HD2,
urn:biopax:UnificationXref:UNIPROT_Q9UDK3
|
| biopax3:displayName |
KC1A_HUMAN
|
| biopax3:name |
2.7.11.1,
CK1,
CKI-alpha,
CSNK1A1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:KC1A_HUMAN_1,
urn:biopax:ModificationFeature:KC1A_HUMAN_2,
urn:biopax:ModificationFeature:KC1A_HUMAN_3,
urn:biopax:ModificationFeature:KC1A_HUMAN_4,
urn:biopax:ModificationFeature:KC1A_HUMAN_5,
urn:biopax:ModificationFeature:KC1A_HUMAN_6,
urn:biopax:ModificationFeature:KC1A_HUMAN_7,
urn:biopax:ModificationFeature:KC1A_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
|
| biopax3:standardName |
Casein kinase I isoform alpha
|