| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. CATALYTIC ACTIVITY: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. ENZYME REGULATION: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction; SUBUNIT: Interacts with KAT5. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. TISSUE SPECIFICITY: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. DOMAIN: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+). PTM: Activated by phosphorylation at both Ser-505 and Ser-727. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 PLA2c domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g4a/"; GENE SYNONYMS:PLA2G4A CPLA2 PLA2G4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 749 AA; 85239 MW; EE71CA0EBE617856 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
PA24A_HUMAN
|
| biopax3:name |
3.1.1.4,
3.1.1.5,
Lysophospholipase,
PLA2G4A,
Phosphatidylcholine 2-acylhydrolase,
Phospholipase A2,
Phospholipase A2 group IVA,
cPLA2
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PA24A_HUMAN_1,
urn:biopax:ModificationFeature:PA24A_HUMAN_2,
urn:biopax:ModificationFeature:PA24A_HUMAN_3,
urn:biopax:ModificationFeature:PA24A_HUMAN_4,
urn:biopax:ModificationFeature:PA24A_HUMAN_5,
urn:biopax:ModificationFeature:PA24A_HUMAN_6,
urn:biopax:ModificationFeature:PA24A_HUMAN_7,
urn:biopax:ModificationFeature:PA24A_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA
|
| biopax3:standardName |
Cytosolic phospholipase A2
|