| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3- carboxymuconate semialdehyde. COFACTOR: Fe(2+) ion. PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P46952-1; Sequence=Displayed; Name=2; IsoId=P46952-2; Sequence=VSP_036239; SIMILARITY: Belongs to the 3-HAO family. GENE SYNONYMS:HAAO. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 286 AA; 32556 MW; 4DA6AC20FC6EC885 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4796,
urn:biopax:RelationshipXref:NCBI GENE_23498,
urn:biopax:RelationshipXref:REFSEQ_NP_036337,
urn:biopax:UnificationXref:UNIPROT_A6NE56,
urn:biopax:UnificationXref:UNIPROT_B4DIN2,
urn:biopax:UnificationXref:UNIPROT_P46952,
urn:biopax:UnificationXref:UNIPROT_Q53QZ7,
urn:biopax:UnificationXref:UNIPROT_Q8N6N9
|
| biopax3:displayName |
3HAO_HUMAN
|
| biopax3:name |
1.13.11.6,
3-HAO,
3-hydroxyanthranilate oxygenase,
3-hydroxyanthranilic acid dioxygenase,
HAAO,
HAD
|
| biopax3:organism | |
| biopax3:sequence |
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG
|
| biopax3:standardName |
3-hydroxyanthranilate 3,4-dioxygenase
|