| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. PATHWAY: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P46597-1; Sequence=Displayed; Name=2; IsoId=P46597-2; Sequence=VSP_004285; Name=3; IsoId=P46597-3; Sequence=VSP_004284; Note=Includes part of a LINE-1 element. Ref.1 (AAA58582/AAA58583/AAA75290), Ref.2 (AAA17020) and Ref.3 (BAG37430) sequences are in conflict in position: 190:W->R; TISSUE SPECIFICITY: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). INDUCTION: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79. MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. SIMILARITY: Belongs to the methyltransferase superfamily. WEB RESOURCE: Name=Wikipedia; Note=5-hydroxyindole-O- methyltransferase entry; URL="http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase"; GENE SYNONYMS:ASMT. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 345 AA; 38453 MW; 187A375E1E2940B7 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:750,
urn:biopax:RelationshipXref:NCBI GENE_438,
urn:biopax:RelationshipXref:REFSEQ_NP_001164509,
urn:biopax:RelationshipXref:REFSEQ_NP_001164510,
urn:biopax:RelationshipXref:REFSEQ_NP_004034,
urn:biopax:UnificationXref:UNIPROT_B2RC33,
urn:biopax:UnificationXref:UNIPROT_P46597,
urn:biopax:UnificationXref:UNIPROT_Q16598,
urn:biopax:UnificationXref:UNIPROT_Q5JQ72,
urn:biopax:UnificationXref:UNIPROT_Q5JQ73
|
| biopax3:displayName |
ASMT_HUMAN
|
| biopax3:name |
2.1.1.4,
ASMT,
HIOMT,
Hydroxyindole O-methyltransferase
|
| biopax3:organism | |
| biopax3:sequence |
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVFPLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
|
| biopax3:standardName |
Acetylserotonin O-methyltransferase
|