| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Note=Known as EP3D in PubMed:8075855; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Note=Known as EP3E in PubMed:8075855; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Note=Known as EP3F in PubMed:8075855; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; TISSUE SPECIFICITY: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. GENE SYNONYMS:PTGER3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 390 AA; 43310 MW; BC76EAC78FDF5420 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:9595,
urn:biopax:RelationshipXref:NCBI GENE_5733,
urn:biopax:RelationshipXref:REFSEQ_NP_001119516,
urn:biopax:RelationshipXref:REFSEQ_NP_942007,
urn:biopax:RelationshipXref:REFSEQ_NP_942008,
urn:biopax:RelationshipXref:REFSEQ_NP_942009,
urn:biopax:RelationshipXref:REFSEQ_NP_942010,
urn:biopax:RelationshipXref:REFSEQ_NP_942011,
urn:biopax:RelationshipXref:REFSEQ_NP_942012,
urn:biopax:UnificationXref:UNIPROT_B0AZN4,
urn:biopax:UnificationXref:UNIPROT_B5BUP5,
urn:biopax:UnificationXref:UNIPROT_O00326,
urn:biopax:UnificationXref:UNIPROT_P43115,
urn:biopax:UnificationXref:UNIPROT_Q12943,
urn:biopax:UnificationXref:UNIPROT_Q12944,
urn:biopax:UnificationXref:UNIPROT_Q12945,
urn:biopax:UnificationXref:UNIPROT_Q16546
|
| biopax3:displayName |
PE2R3_HUMAN
|
| biopax3:name |
PGE receptor EP3 subtype,
PGE2 receptor EP3 subtype,
PGE2-R,
PTGER3,
Prostanoid EP3 receptor
|
| biopax3:organism | |
| biopax3:sequence |
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
|
| biopax3:standardName |
Prostaglandin E2 receptor EP3 subtype
|