| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 2 magnesium or manganese ions per subunit. SUBUNIT: Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Alpha-1; IsoId=P35813-1; Sequence=Displayed; Name=Alpha-2; IsoId=P35813-2; Sequence=VSP_005085, VSP_005086; SIMILARITY: Belongs to the PP2C family. GENE SYNONYMS:PPM1A PPPM1A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 382 AA; 42448 MW; D48EF508B4A76687 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:9275,
urn:biopax:RelationshipXref:NCBI GENE_5494,
urn:biopax:RelationshipXref:REFSEQ_NP_066283,
urn:biopax:RelationshipXref:REFSEQ_NP_808820,
urn:biopax:RelationshipXref:REFSEQ_NP_808821,
urn:biopax:UnificationXref:UNIPROT_B5BU11,
urn:biopax:UnificationXref:UNIPROT_O75551,
urn:biopax:UnificationXref:UNIPROT_P35813
|
| biopax3:displayName |
PPM1A_HUMAN
|
| biopax3:name |
3.1.3.16,
PP2C-alpha,
PPM1A,
Protein phosphatase 2C isoform alpha,
Protein phosphatase IA
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW
|
| biopax3:standardName |
Protein phosphatase 1A
|