| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. SUBUNIT: Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta- 2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=P32297-2; Sequence=Displayed; Name=1; IsoId=P32297-1; Sequence=VSP_037750; Name=3; IsoId=P32297-3; Sequence=VSP_037751; POLYMORPHISM: Genetic variations in CHRNA3 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM:612052]. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. GENE SYNONYMS:CHRNA3 NACHRA3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 505 AA; 57480 MW; 478D7712D59ACB2D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1957,
urn:biopax:RelationshipXref:NCBI GENE_1136,
urn:biopax:RelationshipXref:REFSEQ_NP_000734,
urn:biopax:RelationshipXref:REFSEQ_NP_001160166,
urn:biopax:UnificationXref:UNIPROT_P32297,
urn:biopax:UnificationXref:UNIPROT_Q15823,
urn:biopax:UnificationXref:UNIPROT_Q4KMN8,
urn:biopax:UnificationXref:UNIPROT_Q86U77,
urn:biopax:UnificationXref:UNIPROT_Q96RH3,
urn:biopax:UnificationXref:UNIPROT_Q99553,
urn:biopax:UnificationXref:UNIPROT_Q9BQ93,
urn:biopax:UnificationXref:UNIPROT_Q9BRR4
|
| biopax3:displayName |
ACHA3_HUMAN
|
| biopax3:name |
CHRNA3
|
| biopax3:organism | |
| biopax3:sequence |
MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
|
| biopax3:standardName |
Neuronal acetylcholine receptor subunit alpha-3
|