| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). SUBUNIT: Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA- dependent. Interacts with MBNL1; the interaction in RNA- independent. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. TISSUE SPECIFICITY: Expressed ubiquitously. INDUCTION: Up-regulated in myotonic dystrophy pathophysiology (DM). DOMAIN: Each quasi-RRM repeat bound poly(RG), while only the N- terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA). SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. GENE SYNONYMS:HNRNPH1 HNRPH HNRPH1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 449 AA; 49229 MW; 4ECF7A075C2526FF CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5041,
urn:biopax:RelationshipXref:NCBI GENE_3187,
urn:biopax:RelationshipXref:REFSEQ_NP_001244222,
urn:biopax:RelationshipXref:REFSEQ_NP_005511,
urn:biopax:UnificationXref:UNIPROT_B3KW86,
urn:biopax:UnificationXref:UNIPROT_D3DWQ2,
urn:biopax:UnificationXref:UNIPROT_P31943,
urn:biopax:UnificationXref:UNIPROT_Q6IBM4
|
| biopax3:displayName |
HNRH1_HUMAN
|
| biopax3:name |
HNRNPH1,
Heterogeneous nuclear ribonucleoprotein H, N-terminally processed,
hnRNP H
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:HNRH1_HUMAN_1,
urn:biopax:ModificationFeature:HNRH1_HUMAN_10,
urn:biopax:ModificationFeature:HNRH1_HUMAN_11,
urn:biopax:ModificationFeature:HNRH1_HUMAN_12,
urn:biopax:ModificationFeature:HNRH1_HUMAN_13,
urn:biopax:ModificationFeature:HNRH1_HUMAN_2,
urn:biopax:ModificationFeature:HNRH1_HUMAN_3,
urn:biopax:ModificationFeature:HNRH1_HUMAN_4,
urn:biopax:ModificationFeature:HNRH1_HUMAN_5,
urn:biopax:ModificationFeature:HNRH1_HUMAN_6,
urn:biopax:ModificationFeature:HNRH1_HUMAN_7,
urn:biopax:ModificationFeature:HNRH1_HUMAN_8,
urn:biopax:ModificationFeature:HNRH1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA
|
| biopax3:standardName |
Heterogeneous nuclear ribonucleoprotein H
|