| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Cell surface proteoglycan that bears heparan sulfate. SUBUNIT: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form (By similarity). TISSUE SPECIFICITY: Expressed in epithelial and fibroblastic cells. PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. SIMILARITY: Belongs to the syndecan proteoglycan family. GENE SYNONYMS:SDC4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 198 AA; 21642 MW; 8229AA2733F77A10 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:10661,
urn:biopax:RelationshipXref:NCBI GENE_6385,
urn:biopax:RelationshipXref:REFSEQ_NP_002990,
urn:biopax:UnificationXref:UNIPROT_O00773,
urn:biopax:UnificationXref:UNIPROT_P31431,
urn:biopax:UnificationXref:UNIPROT_Q16833,
urn:biopax:UnificationXref:UNIPROT_Q53FN9
|
| biopax3:displayName |
SDC4_HUMAN
|
| biopax3:name |
Amphiglycan,
Ryudocan core protein,
SDC4,
SYND4
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
|
| biopax3:standardName |
Syndecan-4
|