| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. SUBUNIT: Interacts with MPDZ. Interacts with ARRB2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. DOMAIN: The PDZ domain-binding motif is involved in the interaction with MPDZ. PTM: N-glycosylated. RNA EDITING: Modified_positions=156, 158, 160; Note=Partially edited. RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the central nervous system. POLYMORPHISM: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. GENE SYNONYMS:HTR2C HTR1C. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 458 AA; 51821 MW; 9E76B3FFD3E09C93 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5295,
urn:biopax:RelationshipXref:NCBI GENE_3358,
urn:biopax:RelationshipXref:REFSEQ_NP_000859,
urn:biopax:RelationshipXref:REFSEQ_NP_001243689,
urn:biopax:RelationshipXref:REFSEQ_NP_001243690,
urn:biopax:UnificationXref:UNIPROT_P28335,
urn:biopax:UnificationXref:UNIPROT_Q5VUF8,
urn:biopax:UnificationXref:UNIPROT_Q9NP28
|
| biopax3:displayName |
5HT2C_HUMAN
|
| biopax3:name |
5-HT-1C,
5-HT-2C,
5-HT1C,
5-HT2C,
5-HTR2C,
5-hydroxytryptamine receptor 1C,
HTR2C,
Serotonin receptor 2C
|
| biopax3:organism | |
| biopax3:sequence |
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
|
| biopax3:standardName |
5-hydroxytryptamine receptor 2C
|