| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. SUBUNIT: Interacts with MAPK3/ERK1. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. PTM: Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). SIMILARITY: Belongs to the calreticulin family. WEB RESOURCE: Name=Wikipedia; Note=Calnexin entry; URL="http://en.wikipedia.org/wiki/Calnexin"; GENE SYNONYMS:CANX. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 592 AA; 67568 MW; EDE094D9B82261EE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1473,
urn:biopax:RelationshipXref:NCBI GENE_821,
urn:biopax:RelationshipXref:REFSEQ_NP_001019820,
urn:biopax:RelationshipXref:REFSEQ_NP_001737,
urn:biopax:UnificationXref:UNIPROT_B2R5V8,
urn:biopax:UnificationXref:UNIPROT_D3DWQ3,
urn:biopax:UnificationXref:UNIPROT_P27824
|
| biopax3:displayName |
CALX_HUMAN
|
| biopax3:name |
CANX,
IP90,
Major histocompatibility complex class I antigen-binding protein p88,
p90
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE
|
| biopax3:standardName |
Calnexin
|