| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: This is a receptor for interleukin-3. SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SP1; IsoId=P26951-1; Sequence=Displayed; Name=2; Synonyms=SP2; IsoId=P26951-2; Sequence=VSP_040622; DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. DOMAIN: The box 1 motif is required for JAK interaction and/or activation. MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. SIMILARITY: Belongs to the type I cytokine receptor family. Type 5 subfamily. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL3RAID40959chXp22Yp13.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il3ra/"; GENE SYNONYMS:IL3RA IL3R. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 378 AA; 43330 MW; 716CE1803F2E5FC0 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6012,
urn:biopax:RelationshipXref:NCBI GENE_3563,
urn:biopax:RelationshipXref:REFSEQ_NP_002174,
urn:biopax:UnificationXref:UNIPROT_A8K3F3,
urn:biopax:UnificationXref:UNIPROT_B9VI81,
urn:biopax:UnificationXref:UNIPROT_P26951,
urn:biopax:UnificationXref:UNIPROT_Q5HYQ7
|
| biopax3:displayName |
IL3RA_HUMAN
|
| biopax3:name |
CD123,
IL-3 receptor subunit alpha,
IL-3R subunit alpha,
IL-3R-alpha,
IL-3RA,
IL3RA
|
| biopax3:organism | |
| biopax3:sequence |
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
|
| biopax3:standardName |
Interleukin-3 receptor subunit alpha
|