| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. SUBUNIT: Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P26368-1; Sequence=Displayed; Name=2; IsoId=P26368-2; Sequence=VSP_035414; PTM: Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. GENE SYNONYMS:U2AF2 U2AF65. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 475 AA; 53501 MW; 26AD271CD8FC6211 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
U2AF2_HUMAN
|
| biopax3:name |
U2 auxiliary factor 65 kDa subunit,
U2 snRNP auxiliary factor large subunit,
U2AF2,
hU2AF(65),
hU2AF65
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:U2AF2_HUMAN_1,
urn:biopax:ModificationFeature:U2AF2_HUMAN_2,
urn:biopax:ModificationFeature:U2AF2_HUMAN_3,
urn:biopax:ModificationFeature:U2AF2_HUMAN_4,
urn:biopax:ModificationFeature:U2AF2_HUMAN_5,
urn:biopax:ModificationFeature:U2AF2_HUMAN_6,
urn:biopax:ModificationFeature:U2AF2_HUMAN_7,
urn:biopax:ModificationFeature:U2AF2_HUMAN_8,
urn:biopax:ModificationFeature:U2AF2_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
|
| biopax3:standardName |
Splicing factor U2AF 65 kDa subunit
|