| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. SUBUNIT: Binds IGF2 more than IGF1. SUBCELLULAR LOCATION: Secreted. INDUCTION: By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 1 thyroglobulin type-1 domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp4/"; GENE SYNONYMS:IGFBP4 IBP4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 258 AA; 27934 MW; 5E8F4638D99F0A94 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5473,
urn:biopax:RelationshipXref:NCBI GENE_3487,
urn:biopax:RelationshipXref:REFSEQ_NP_001543,
urn:biopax:UnificationXref:UNIPROT_A0N9W2,
urn:biopax:UnificationXref:UNIPROT_P22692,
urn:biopax:UnificationXref:UNIPROT_Q5U012,
urn:biopax:UnificationXref:UNIPROT_Q9UCL6
|
| biopax3:displayName |
IBP4_HUMAN
|
| biopax3:name |
IBP-4,
IGF-binding protein 4,
IGFBP-4,
IGFBP4
|
| biopax3:organism | |
| biopax3:sequence |
MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
|
| biopax3:standardName |
Insulin-like growth factor-binding protein 4
|