P22626

FUNCTION: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. SUBUNIT: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=B1; IsoId=P22626-1; Sequence=Displayed; Name=A2; IsoId=P22626-2; Sequence=VSP_005830; SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. GENE SYNONYMS:HNRNPA2B1 HNRPA2B1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 353 AA; 37430 MW; 4C2560A3D8E99D62 CRC64;

ROA2_HUMAN

urn:biopax:ModificationFeature:ROA2_HUMAN_1, urn:biopax:ModificationFeature:ROA2_HUMAN_10, urn:biopax:ModificationFeature:ROA2_HUMAN_11, urn:biopax:ModificationFeature:ROA2_HUMAN_12, urn:biopax:ModificationFeature:ROA2_HUMAN_13, urn:biopax:ModificationFeature:ROA2_HUMAN_14, urn:biopax:ModificationFeature:ROA2_HUMAN_15, urn:biopax:ModificationFeature:ROA2_HUMAN_16, urn:biopax:ModificationFeature:ROA2_HUMAN_17, urn:biopax:ModificationFeature:ROA2_HUMAN_18, urn:biopax:ModificationFeature:ROA2_HUMAN_2, urn:biopax:ModificationFeature:ROA2_HUMAN_3, urn:biopax:ModificationFeature:ROA2_HUMAN_4, urn:biopax:ModificationFeature:ROA2_HUMAN_5, urn:biopax:ModificationFeature:ROA2_HUMAN_6, urn:biopax:ModificationFeature:ROA2_HUMAN_7, urn:biopax:ModificationFeature:ROA2_HUMAN_8, urn:biopax:ModificationFeature:ROA2_HUMAN_9

MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY