Linked Life Data

P20851

Source:http://identifiers.org/uniprot/P20851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. SUBUNIT: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20851-1; Sequence=Displayed; Name=2; IsoId=P20851-2; Sequence=VSP_022594; Note=No experimental confirmation available; SIMILARITY: Contains 3 Sushi (CCP/SCR) domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/c4bpb/"; GENE SYNONYMS:C4BPB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 252 AA; 28357 MW; 0F6CC64067C5E2E7 CRC64;
biopax3:xref
biopax3:displayName
C4BPB_HUMAN
biopax3:name
C4BPB
biopax3:organism
biopax3:sequence
MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL
biopax3:standardName
C4b-binding protein beta chain