| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells. PHARMACEUTICAL: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL2 entry; URL="http://en.wikipedia.org/wiki/CXCL2"; GENE SYNONYMS:CXCL2 GRO2 GROB MIP2A SCYB2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 107 AA; 11389 MW; 740F277E928571BA CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
CXCL2_HUMAN
|
| biopax3:name |
CXCL2,
GRO-beta(5-73),
GRO-beta-T,
Gro-beta,
Growth-regulated protein beta,
HSF,
Hematopoietic synergistic factor,
MIP2-alpha,
Macrophage inflammatory protein 2-alpha,
SB-251353
|
| biopax3:organism | |
| biopax3:sequence |
MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN
|
| biopax3:standardName |
C-X-C motif chemokine 2
|