Linked Life Data

P17936

Source:http://identifiers.org/uniprot/P17936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. SUBUNIT: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by most tissues. Present in plasma. DEVELOPMENTAL STAGE: IGFBP3 levels are higher during extrauterine life and peak during puberty. INDUCTION: Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters. DOMAIN: The thyroglobulin type-1 domain mediates interaction with HN. PTM: Phosphorylation sites are present in the extracelllular medium. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 1 thyroglobulin type-1 domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp3/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3"; GENE SYNONYMS:IGFBP3 IBP3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 291 AA; 31674 MW; A9682065AB266586 CRC64;
biopax3:xref
biopax3:displayName
IBP3_HUMAN
biopax3:name
IBP-3, IGF-binding protein 3, IGFBP-3, IGFBP3
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
biopax3:standardName
Insulin-like growth factor-binding protein 3