| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. FUNCTION: Isoform 4/ATF-A0 acts as a dominant repressor of the E- selectin/NF-ELAM1/delta-A promoter. FUNCTION: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. SUBUNIT: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF- associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery. SUBCELLULAR LOCATION: Isoform 5: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=3; Synonyms=ATF-A1; IsoId=P17544-1; Sequence=Displayed; Name=1; Synonyms=ATF-A; IsoId=P17544-2; Sequence=VSP_000594, VSP_000595; Name=2; Synonyms=ATF-A-delta; IsoId=P17544-3; Sequence=VSP_000595; Name=4; Synonyms=ATF-A0; IsoId=P17544-4; Sequence=VSP_000594, VSP_034543; Name=5; Synonyms=ATF-4; IsoId=P17544-5; Sequence=VSP_042469; Name=6; IsoId=P17544-6; Sequence=VSP_000594; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. PTM: On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity. PTM: Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase. SIMILARITY: Belongs to the bZIP family. SIMILARITY: Contains 1 bZIP domain. SIMILARITY: Contains 1 C2H2-type zinc finger. GENE SYNONYMS:ATF7 ATFA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 494 AA; 52967 MW; 511EAF79C6503300 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:792,
urn:biopax:RelationshipXref:NCBI GENE_11016,
urn:biopax:RelationshipXref:REFSEQ_NP_001123531,
urn:biopax:RelationshipXref:REFSEQ_NP_001123532,
urn:biopax:RelationshipXref:REFSEQ_NP_001193611,
urn:biopax:RelationshipXref:REFSEQ_NP_001193612,
urn:biopax:RelationshipXref:REFSEQ_NP_006847,
urn:biopax:UnificationXref:UNIPROT_A5D6Y4,
urn:biopax:UnificationXref:UNIPROT_B2RMP1,
urn:biopax:UnificationXref:UNIPROT_B4DQL4,
urn:biopax:UnificationXref:UNIPROT_P17544,
urn:biopax:UnificationXref:UNIPROT_Q13814,
urn:biopax:UnificationXref:UNIPROT_Q8IVR8,
urn:biopax:UnificationXref:UNIPROT_Q9UD83
|
| biopax3:displayName |
ATF7_HUMAN
|
| biopax3:name |
ATF7,
Activating transcription factor 7,
Transcription factor ATF-A,
cAMP-dependent transcription factor ATF-7
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:ATF7_HUMAN_1,
urn:biopax:ModificationFeature:ATF7_HUMAN_10,
urn:biopax:ModificationFeature:ATF7_HUMAN_11,
urn:biopax:ModificationFeature:ATF7_HUMAN_12,
urn:biopax:ModificationFeature:ATF7_HUMAN_13,
urn:biopax:ModificationFeature:ATF7_HUMAN_14,
urn:biopax:ModificationFeature:ATF7_HUMAN_2,
urn:biopax:ModificationFeature:ATF7_HUMAN_3,
urn:biopax:ModificationFeature:ATF7_HUMAN_4,
urn:biopax:ModificationFeature:ATF7_HUMAN_5,
urn:biopax:ModificationFeature:ATF7_HUMAN_6,
urn:biopax:ModificationFeature:ATF7_HUMAN_7,
urn:biopax:ModificationFeature:ATF7_HUMAN_8,
urn:biopax:ModificationFeature:ATF7_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAEAVATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR
|
| biopax3:standardName |
Cyclic AMP-dependent transcription factor ATF-7
|