| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. SUBUNIT: Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P12814-1; Sequence=Displayed; Name=2; IsoId=P12814-2; Sequence=VSP_041264; Name=3; IsoId=P12814-3; Sequence=VSP_043525; SIMILARITY: Belongs to the alpha-actinin family. SIMILARITY: Contains 1 actin-binding domain. SIMILARITY: Contains 2 CH (calponin-homology) domains. SIMILARITY: Contains 2 EF-hand domains. SIMILARITY: Contains 4 spectrin repeats. GENE SYNONYMS:ACTN1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 892 AA; 103058 MW; 6DA3E4D1A0289519 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:163,
urn:biopax:RelationshipXref:NCBI GENE_87,
urn:biopax:RelationshipXref:REFSEQ_NP_001093,
urn:biopax:RelationshipXref:REFSEQ_NP_001123476,
urn:biopax:RelationshipXref:REFSEQ_NP_001123477,
urn:biopax:UnificationXref:UNIPROT_B3V8S3,
urn:biopax:UnificationXref:UNIPROT_B4DHH3,
urn:biopax:UnificationXref:UNIPROT_P12814,
urn:biopax:UnificationXref:UNIPROT_Q1HE25,
urn:biopax:UnificationXref:UNIPROT_Q9BTN1
|
| biopax3:displayName |
ACTN1_HUMAN
|
| biopax3:name |
ACTN1,
Alpha-actinin cytoskeletal isoform,
F-actin cross-linking protein,
Non-muscle alpha-actinin-1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:ACTN1_HUMAN_1,
urn:biopax:ModificationFeature:ACTN1_HUMAN_2,
urn:biopax:ModificationFeature:ACTN1_HUMAN_3,
urn:biopax:ModificationFeature:ACTN1_HUMAN_4,
urn:biopax:ModificationFeature:ACTN1_HUMAN_5,
urn:biopax:ModificationFeature:ACTN1_HUMAN_6,
urn:biopax:ModificationFeature:ACTN1_HUMAN_7,
urn:biopax:ModificationFeature:ACTN1_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
|
| biopax3:standardName |
Alpha-actinin-1
|