| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity. CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O. COFACTOR: Heme group. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.23 uM for coumarin; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Liver. INDUCTION: By phenobarbital and dexamethasone. SIMILARITY: Belongs to the cytochrome P450 family. SEQUENCE CAUTION: Sequence=AAA52147.1; Type=Miscellaneous discrepancy; Note=Numerous conflicts and frameshifts; WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2A6 alleles; URL="http://www.cypalleles.ki.se/cyp2a6.htm"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2a6/"; WEB RESOURCE: Name=Wikipedia; Note=CYP2A6 entry; URL="http://en.wikipedia.org/wiki/CYP2A6"; GENE SYNONYMS:CYP2A6 CYP2A3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 494 AA; 56501 MW; 8C05CBF0EFC698AF CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2610,
urn:biopax:RelationshipXref:NCBI GENE_1548,
urn:biopax:RelationshipXref:REFSEQ_NP_000753,
urn:biopax:UnificationXref:UNIPROT_A7YAE5,
urn:biopax:UnificationXref:UNIPROT_B2R7F6,
urn:biopax:UnificationXref:UNIPROT_P00190,
urn:biopax:UnificationXref:UNIPROT_P10890,
urn:biopax:UnificationXref:UNIPROT_P11509,
urn:biopax:UnificationXref:UNIPROT_Q16803,
urn:biopax:UnificationXref:UNIPROT_Q4VAT9,
urn:biopax:UnificationXref:UNIPROT_Q4VAU0,
urn:biopax:UnificationXref:UNIPROT_Q4VAU1,
urn:biopax:UnificationXref:UNIPROT_Q9H1Z7,
urn:biopax:UnificationXref:UNIPROT_Q9UCU0,
urn:biopax:UnificationXref:UNIPROT_Q9UK48
|
| biopax3:displayName |
CP2A6_HUMAN
|
| biopax3:name |
1.14.14.1,
CYP2A6,
CYPIIA6,
Coumarin 7-hydroxylase,
Cytochrome P450 IIA3,
Cytochrome P450(I)
|
| biopax3:organism | |
| biopax3:sequence |
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR
|
| biopax3:standardName |
Cytochrome P450 2A6
|