| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA. ENZYME REGULATION: Specifically inhibited by the intercalating agent amsacrine. SUBUNIT: Homodimer. Interacts with COPS5. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P11388-1; Sequence=Displayed; Name=2; IsoId=P11388-2; Sequence=VSP_006531; Name=3; IsoId=P11388-3; Sequence=VSP_006529; Name=4; IsoId=P11388-4; Sequence=VSP_006530; PTM: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation. MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. SIMILARITY: Belongs to the type II topoisomerase family. GENE SYNONYMS:TOP2A TOP2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1531 AA; 174385 MW; 3DF40BC9E84789DC CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11989,
urn:biopax:RelationshipXref:NCBI GENE_7153,
urn:biopax:RelationshipXref:REFSEQ_NP_001058,
urn:biopax:UnificationXref:UNIPROT_B2RTS1,
urn:biopax:UnificationXref:UNIPROT_P11388,
urn:biopax:UnificationXref:UNIPROT_Q71UN1,
urn:biopax:UnificationXref:UNIPROT_Q71UQ5,
urn:biopax:UnificationXref:UNIPROT_Q9HB24,
urn:biopax:UnificationXref:UNIPROT_Q9HB25,
urn:biopax:UnificationXref:UNIPROT_Q9HB26,
urn:biopax:UnificationXref:UNIPROT_Q9UP44,
urn:biopax:UnificationXref:UNIPROT_Q9UQP9
|
| biopax3:displayName |
TOP2A_HUMAN
|
| biopax3:name |
5.99.1.3,
DNA topoisomerase II, alpha isozyme,
TOP2A
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:TOP2A_HUMAN_1,
urn:biopax:ModificationFeature:TOP2A_HUMAN_10,
urn:biopax:ModificationFeature:TOP2A_HUMAN_11,
urn:biopax:ModificationFeature:TOP2A_HUMAN_12,
urn:biopax:ModificationFeature:TOP2A_HUMAN_13,
urn:biopax:ModificationFeature:TOP2A_HUMAN_14,
urn:biopax:ModificationFeature:TOP2A_HUMAN_15,
urn:biopax:ModificationFeature:TOP2A_HUMAN_16,
urn:biopax:ModificationFeature:TOP2A_HUMAN_17,
urn:biopax:ModificationFeature:TOP2A_HUMAN_18,
urn:biopax:ModificationFeature:TOP2A_HUMAN_19,
urn:biopax:ModificationFeature:TOP2A_HUMAN_2,
urn:biopax:ModificationFeature:TOP2A_HUMAN_20,
urn:biopax:ModificationFeature:TOP2A_HUMAN_21,
urn:biopax:ModificationFeature:TOP2A_HUMAN_22,
urn:biopax:ModificationFeature:TOP2A_HUMAN_23,
urn:biopax:ModificationFeature:TOP2A_HUMAN_24,
urn:biopax:ModificationFeature:TOP2A_HUMAN_25,
urn:biopax:ModificationFeature:TOP2A_HUMAN_26,
urn:biopax:ModificationFeature:TOP2A_HUMAN_27,
urn:biopax:ModificationFeature:TOP2A_HUMAN_28,
urn:biopax:ModificationFeature:TOP2A_HUMAN_29,
urn:biopax:ModificationFeature:TOP2A_HUMAN_3,
urn:biopax:ModificationFeature:TOP2A_HUMAN_30,
urn:biopax:ModificationFeature:TOP2A_HUMAN_4,
urn:biopax:ModificationFeature:TOP2A_HUMAN_5,
urn:biopax:ModificationFeature:TOP2A_HUMAN_6,
urn:biopax:ModificationFeature:TOP2A_HUMAN_7,
urn:biopax:ModificationFeature:TOP2A_HUMAN_8,
urn:biopax:ModificationFeature:TOP2A_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
|
| biopax3:standardName |
DNA topoisomerase 2-alpha
|