| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Alpha; Synonyms=TFPIalpha; IsoId=P10646-1; Sequence=Displayed; Name=Beta; Synonyms=TFPIbeta; IsoId=P10646-2; Sequence=VSP_003030, VSP_003031; TISSUE SPECIFICITY: Mostly in endothelial cells. DOMAIN: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa. PTM: O-glycosylated. SIMILARITY: Contains 3 BPTI/Kunitz inhibitor domains. WEB RESOURCE: Name=Wikipedia; Note=TFPI entry; URL="http://en.wikipedia.org/wiki/TFPI"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tfpi/"; GENE SYNONYMS:TFPI LACI TFPI1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 304 AA; 35015 MW; 5281E32B758B44FE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11760,
urn:biopax:RelationshipXref:NCBI GENE_7035,
urn:biopax:RelationshipXref:REFSEQ_NP_001027452,
urn:biopax:RelationshipXref:REFSEQ_NP_006278,
urn:biopax:UnificationXref:UNIPROT_O95103,
urn:biopax:UnificationXref:UNIPROT_P10646,
urn:biopax:UnificationXref:UNIPROT_Q53TS4
|
| biopax3:displayName |
TFPI1_HUMAN
|
| biopax3:name |
EPI,
Extrinsic pathway inhibitor,
LACI,
Lipoprotein-associated coagulation inhibitor,
TFPI
|
| biopax3:organism | |
| biopax3:sequence |
MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
|
| biopax3:standardName |
Tissue factor pathway inhibitor
|