P10451

FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity). SUBUNIT: Ligand for integrin alpha-V/beta-3. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=A; Synonyms=OPN-a, OP1B; IsoId=P10451-1; Sequence=Displayed; Name=B; Synonyms=OPN-b, OP1A; IsoId=P10451-2; Sequence=VSP_003778; Name=C; Synonyms=OPN-c; IsoId=P10451-3; Sequence=VSP_003777; Name=D; IsoId=P10451-4; Sequence=VSP_011639; Name=5; IsoId=P10451-5; Sequence=VSP_043695; Note=No experimental confirmation available; TISSUE SPECIFICITY: Bone. Found in plasma. PTM: Extensively phosphorylated by FAM20C in the extracelllular medium at multiple sites within the S-x-E/pS motif. PTM: N- and O-glycosylated. SIMILARITY: Belongs to the osteopontin family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SPP1ID42379ch4q22.html"; WEB RESOURCE: Name=Wikipedia; Note=Osteopontin entry; URL="http://en.wikipedia.org/wiki/Osteopontin"; GENE SYNONYMS:SPP1 BNSP OPN. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 314 AA; 35423 MW; 4996429EC4752B86 CRC64;

OSTP_HUMAN

urn:biopax:ModificationFeature:OSTP_HUMAN_1, urn:biopax:ModificationFeature:OSTP_HUMAN_10, urn:biopax:ModificationFeature:OSTP_HUMAN_11, urn:biopax:ModificationFeature:OSTP_HUMAN_12, urn:biopax:ModificationFeature:OSTP_HUMAN_13, urn:biopax:ModificationFeature:OSTP_HUMAN_14, urn:biopax:ModificationFeature:OSTP_HUMAN_15, urn:biopax:ModificationFeature:OSTP_HUMAN_16, urn:biopax:ModificationFeature:OSTP_HUMAN_17, urn:biopax:ModificationFeature:OSTP_HUMAN_18, urn:biopax:ModificationFeature:OSTP_HUMAN_19, urn:biopax:ModificationFeature:OSTP_HUMAN_2, urn:biopax:ModificationFeature:OSTP_HUMAN_20, urn:biopax:ModificationFeature:OSTP_HUMAN_21, urn:biopax:ModificationFeature:OSTP_HUMAN_22, urn:biopax:ModificationFeature:OSTP_HUMAN_23, urn:biopax:ModificationFeature:OSTP_HUMAN_24, urn:biopax:ModificationFeature:OSTP_HUMAN_25, urn:biopax:ModificationFeature:OSTP_HUMAN_26, urn:biopax:ModificationFeature:OSTP_HUMAN_27, urn:biopax:ModificationFeature:OSTP_HUMAN_28, urn:biopax:ModificationFeature:OSTP_HUMAN_29, urn:biopax:ModificationFeature:OSTP_HUMAN_3, urn:biopax:ModificationFeature:OSTP_HUMAN_30, urn:biopax:ModificationFeature:OSTP_HUMAN_31, urn:biopax:ModificationFeature:OSTP_HUMAN_32, urn:biopax:ModificationFeature:OSTP_HUMAN_33, urn:biopax:ModificationFeature:OSTP_HUMAN_4, urn:biopax:ModificationFeature:OSTP_HUMAN_5, urn:biopax:ModificationFeature:OSTP_HUMAN_6, urn:biopax:ModificationFeature:OSTP_HUMAN_7, urn:biopax:ModificationFeature:OSTP_HUMAN_8, urn:biopax:ModificationFeature:OSTP_HUMAN_9

MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN