| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/adra2a/"; GENE SYNONYMS:ADRA2A ADRA2R ADRAR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 450 AA; 48957 MW; A703CF262F04E8AC CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:281,
urn:biopax:RelationshipXref:NCBI GENE_150,
urn:biopax:RelationshipXref:REFSEQ_NP_000672,
urn:biopax:UnificationXref:UNIPROT_B0LPF6,
urn:biopax:UnificationXref:UNIPROT_P08913,
urn:biopax:UnificationXref:UNIPROT_Q2I8G2,
urn:biopax:UnificationXref:UNIPROT_Q2XN99,
urn:biopax:UnificationXref:UNIPROT_Q86TH8,
urn:biopax:UnificationXref:UNIPROT_Q9BZK1
|
| biopax3:displayName |
ADA2A_HUMAN
|
| biopax3:name |
ADRA2A,
Alpha-2 adrenergic receptor subtype C10,
Alpha-2A adrenoceptor,
Alpha-2A adrenoreceptor,
Alpha-2AAR
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
|
| biopax3:standardName |
Alpha-2A adrenergic receptor
|