| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Conversion of sulfated steroid precursors to estrogens during pregnancy. CATALYTIC ACTIVITY: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. COFACTOR: Binds 1 calcium ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity). DISEASE: Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. SIMILARITY: Belongs to the sulfatase family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/STS"; WEB RESOURCE: Name=Wikipedia; Note=Steroid sulfatase entry; URL="http://en.wikipedia.org/wiki/Steroid_sulfatase"; GENE SYNONYMS:STS ARSC1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 583 AA; 65492 MW; 74746AFA9D21A0A6 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
STS_HUMAN
|
| biopax3:name |
3.1.6.2,
ASC,
Arylsulfatase C,
STS,
Steroid sulfatase,
Steryl-sulfate sulfohydrolase
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
|
| biopax3:standardName |
Steryl-sulfatase
|