| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. SUBUNIT: Component of the CatSper complex (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3. SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. TISSUE SPECIFICITY: HSPA1B is testis-specific. INDUCTION: By heat shock. SIMILARITY: Belongs to the heat shock protein 70 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa1a/"; GENE SYNONYMS:HSPA1A HSPA1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 641 AA; 70052 MW; 78F513118C96DE66 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5232,
urn:biopax:RelationshipXref:HGNC_HGNC:5233,
urn:biopax:RelationshipXref:NCBI GENE_3303,
urn:biopax:RelationshipXref:NCBI GENE_3304,
urn:biopax:RelationshipXref:REFSEQ_NP_005336,
urn:biopax:RelationshipXref:REFSEQ_NP_005337,
urn:biopax:UnificationXref:UNIPROT_P08107,
urn:biopax:UnificationXref:UNIPROT_Q5JQI4,
urn:biopax:UnificationXref:UNIPROT_Q5SP17,
urn:biopax:UnificationXref:UNIPROT_Q9UQL9,
urn:biopax:UnificationXref:UNIPROT_Q9UQM0
|
| biopax3:displayName |
HSP71_HUMAN
|
| biopax3:name |
HSP70-1/HSP70-2,
HSP70.1/HSP70.2,
HSPA1A,
Heat shock 70 kDa protein 1/2
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:HSP71_HUMAN_1,
urn:biopax:ModificationFeature:HSP71_HUMAN_2,
urn:biopax:ModificationFeature:HSP71_HUMAN_3,
urn:biopax:ModificationFeature:HSP71_HUMAN_4,
urn:biopax:ModificationFeature:HSP71_HUMAN_5,
urn:biopax:ModificationFeature:HSP71_HUMAN_6,
urn:biopax:ModificationFeature:HSP71_HUMAN_7,
urn:biopax:ModificationFeature:HSP71_HUMAN_8,
urn:biopax:ModificationFeature:HSP71_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
|
| biopax3:standardName |
Heat shock 70 kDa protein 1A/1B
|