P05783

FUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. SUBUNIT: Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin- antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. INDUCTION: By IL6/interleukin-6. PTM: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. PTM: Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. PTM: O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. DISEASE: Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600]. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org"; GENE SYNONYMS:KRT18 CYK18. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 430 AA; 48058 MW; 1E5604C6BCC7A17A CRC64;

K1C18_HUMAN

urn:biopax:ModificationFeature:K1C18_HUMAN_1, urn:biopax:ModificationFeature:K1C18_HUMAN_10, urn:biopax:ModificationFeature:K1C18_HUMAN_11, urn:biopax:ModificationFeature:K1C18_HUMAN_12, urn:biopax:ModificationFeature:K1C18_HUMAN_13, urn:biopax:ModificationFeature:K1C18_HUMAN_14, urn:biopax:ModificationFeature:K1C18_HUMAN_15, urn:biopax:ModificationFeature:K1C18_HUMAN_16, urn:biopax:ModificationFeature:K1C18_HUMAN_17, urn:biopax:ModificationFeature:K1C18_HUMAN_18, urn:biopax:ModificationFeature:K1C18_HUMAN_19, urn:biopax:ModificationFeature:K1C18_HUMAN_2, urn:biopax:ModificationFeature:K1C18_HUMAN_20, urn:biopax:ModificationFeature:K1C18_HUMAN_21, urn:biopax:ModificationFeature:K1C18_HUMAN_22, urn:biopax:ModificationFeature:K1C18_HUMAN_23, urn:biopax:ModificationFeature:K1C18_HUMAN_24, urn:biopax:ModificationFeature:K1C18_HUMAN_25, urn:biopax:ModificationFeature:K1C18_HUMAN_26, urn:biopax:ModificationFeature:K1C18_HUMAN_27, urn:biopax:ModificationFeature:K1C18_HUMAN_28, urn:biopax:ModificationFeature:K1C18_HUMAN_29, urn:biopax:ModificationFeature:K1C18_HUMAN_3, urn:biopax:ModificationFeature:K1C18_HUMAN_4, urn:biopax:ModificationFeature:K1C18_HUMAN_5, urn:biopax:ModificationFeature:K1C18_HUMAN_6, urn:biopax:ModificationFeature:K1C18_HUMAN_7, urn:biopax:ModificationFeature:K1C18_HUMAN_8, urn:biopax:ModificationFeature:K1C18_HUMAN_9

MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH