Predicate | Object |
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rdf:type | |
biopax3:comment |
FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. DISEASE: Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. SIMILARITY: Belongs to the integrin beta chain family. SIMILARITY: Contains 1 VWFA domain. SEQUENCE CAUTION: Sequence=BAD96225.1; Type=Erroneous initiation; WEB RESOURCE: Name=ITGB2base; Note=ITGB2 mutation db; URL="http://bioinf.uta.fi/ITGB2base/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGB2"; GENE SYNONYMS:ITGB2 CD18 MFI7. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 769 AA; 84782 MW; EB9F3C3DF338B4E1 CRC64;
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biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6155,
urn:biopax:RelationshipXref:NCBI GENE_3689,
urn:biopax:RelationshipXref:REFSEQ_NP_000202,
urn:biopax:RelationshipXref:REFSEQ_NP_001120963,
urn:biopax:UnificationXref:UNIPROT_B3KTS8,
urn:biopax:UnificationXref:UNIPROT_D3DSM1,
urn:biopax:UnificationXref:UNIPROT_P05107,
urn:biopax:UnificationXref:UNIPROT_Q16418,
urn:biopax:UnificationXref:UNIPROT_Q53HS5,
urn:biopax:UnificationXref:UNIPROT_Q9UD72
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biopax3:displayName |
ITB2_HUMAN
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biopax3:name |
CD18,
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta,
Complement receptor C3 subunit beta,
ITGB2
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biopax3:entityFeature | |
biopax3:organism | |
biopax3:sequence |
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
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biopax3:standardName |
Integrin beta-2
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