Linked Life Data

P05019

Source:http://identifiers.org/uniprot/P05019

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=IGF-IB; IsoId=P05019-1; Sequence=Displayed; Name=2; Synonyms=IGF-IA; IsoId=P05019-2; Sequence=VSP_039637; Name=3; IsoId=P05019-3; Sequence=VSP_043317, VSP_039637; Note=Expressed in liver; DISEASE: Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. SIMILARITY: Belongs to the insulin family. SEQUENCE CAUTION: Sequence=CAA27250.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igf1/"; WEB RESOURCE: Name=Wikipedia; Note=Insulin-like growth factor 1 entry; URL="http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1"; GENE SYNONYMS:IGF1 IBP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 195 AA; 21841 MW; E88A8CFBD1CD1873 CRC64;
biopax3:xref
biopax3:displayName
IGF1_HUMAN
biopax3:name
IGF-I, IGF1, MGF, Mechano growth factor, Somatomedin-C
biopax3:organism
biopax3:sequence
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK
biopax3:standardName
Insulin-like growth factor I