| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. SUBUNIT: Homotrimer. In the endoplasmic reticulum (ER) it forms an heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P04233-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P04233-2; Sequence=VSP_005331; Name=3; IsoId=P04233-3; Sequence=VSP_037869, VSP_037870; PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. DISEASE: Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. SIMILARITY: Contains 1 thyroglobulin type-1 domain. SEQUENCE CAUTION: Sequence=AAA36304.1; Type=Erroneous initiation; GENE SYNONYMS:CD74 DHLAG. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 296 AA; 33516 MW; 27A13F252D5FB91D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1697,
urn:biopax:RelationshipXref:NCBI GENE_972,
urn:biopax:RelationshipXref:REFSEQ_NP_001020329,
urn:biopax:RelationshipXref:REFSEQ_NP_001020330,
urn:biopax:RelationshipXref:REFSEQ_NP_004346,
urn:biopax:UnificationXref:UNIPROT_A8K7R1,
urn:biopax:UnificationXref:UNIPROT_B4DNE8,
urn:biopax:UnificationXref:UNIPROT_D3DQG3,
urn:biopax:UnificationXref:UNIPROT_D3DQG4,
urn:biopax:UnificationXref:UNIPROT_P04233,
urn:biopax:UnificationXref:UNIPROT_Q14597,
urn:biopax:UnificationXref:UNIPROT_Q29832,
urn:biopax:UnificationXref:UNIPROT_Q5U0J8,
urn:biopax:UnificationXref:UNIPROT_Q8SNA0,
urn:biopax:UnificationXref:UNIPROT_Q8WLP6
|
| biopax3:displayName |
HG2A_HUMAN
|
| biopax3:name |
CD74,
HLA-DR antigens-associated invariant chain,
Ia antigen-associated invariant chain,
Ii,
p33
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
|
| biopax3:standardName |
HLA class II histocompatibility antigen gamma chain
|